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JMJD3 facilitates C/EBPβ-centered transcriptional program to exert oncorepressor activity in AML
JMJD3, a stress-inducible H3K27 demethylase, plays a critical regulatory role in the initiation and progression of malignant hematopoiesis. However, how this histone modifier affects in a cell type-dependent manner remains unclear. Here, we show that in contrast to its oncogenic effect in preleukemi...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6105679/ https://www.ncbi.nlm.nih.gov/pubmed/30135572 http://dx.doi.org/10.1038/s41467-018-05548-z |