Axonal G3BP1 stress granule protein limits axonal mRNA translation and nerve regeneration

Critical functions of intra-axonally synthesized proteins are thought to depend on regulated recruitment of mRNA from storage depots in axons. Here we show that axotomy of mammalian neurons induces translation of stored axonal mRNAs via regulation of the stress granule protein G3BP1, to support rege...

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Detalles Bibliográficos
Autores principales: Sahoo, Pabitra K., Lee, Seung Joon, Jaiswal, Poonam B., Alber, Stefanie, Kar, Amar N., Miller-Randolph, Sharmina, Taylor, Elizabeth E., Smith, Terika, Singh, Bhagat, Ho, Tammy Szu-Yu, Urisman, Anatoly, Chand, Shreya, Pena, Edsel A., Burlingame, Alma L., Woolf, Clifford J., Fainzilber, Mike, English, Arthur W., Twiss, Jeffery L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6105716/
https://www.ncbi.nlm.nih.gov/pubmed/30135423
http://dx.doi.org/10.1038/s41467-018-05647-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6105716/
https://www.ncbi.nlm.nih.gov/pubmed/30135423
http://dx.doi.org/10.1038/s41467-018-05647-x

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