Antitrypanosomal 8-Hydroxy-Naphthyridines Are Chelators of Divalent Transition Metals

The lack of information regarding the mechanisms of action (MoA) or specific molecular targets of phenotypically active compounds can prove a barrier to their development as chemotherapeutic agents. Here, we report the results of our orthogonal genetic, molecular, and biochemical studies to determin...

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Detalles Bibliográficos
Autores principales: Wall, Richard J., Moniz, Sonia, Thomas, Michael G., Norval, Suzanne, Ko, Eun-Jung, Marco, Maria, Miles, Timothy J., Gilbert, Ian H., Horn, David, Fairlamb, Alan H., Wyllie, Susan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2018
Materias:
Mechanisms of Action: Physiological Effects
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6105827/
https://www.ncbi.nlm.nih.gov/pubmed/29844044
http://dx.doi.org/10.1128/AAC.00235-18

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6105827/
https://www.ncbi.nlm.nih.gov/pubmed/29844044
http://dx.doi.org/10.1128/AAC.00235-18

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