Correlation of Severity of Human Tick-Borne Encephalitis Virus Disease and Pathogenicity in Mice

We compared 2 tick-borne encephalitis virus strains isolated from 2 different foci that cause different symptoms in tick-borne encephalitis patients, from neurologic to mild gastrointestinal symptoms. We compared neuroinvasiveness, neurovirulence, and proinflammatory cytokine response in mice and fo...

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Autores principales: Kurhade, Chaitanya, Schreier, Sarah, Lee, Yi-Ping, Zegenhagen, Loreen, Hjertqvist, Marika, Dobler, Gerhard, Kröger, Andrea, Överby, Anna K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2018
Materias:
Dispatch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6106420/
https://www.ncbi.nlm.nih.gov/pubmed/30124404
http://dx.doi.org/10.3201/eid2409.171825
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author Kurhade, Chaitanya
Schreier, Sarah
Lee, Yi-Ping
Zegenhagen, Loreen
Hjertqvist, Marika
Dobler, Gerhard
Kröger, Andrea
Överby, Anna K.
author_facet Kurhade, Chaitanya
Schreier, Sarah
Lee, Yi-Ping
Zegenhagen, Loreen
Hjertqvist, Marika
Dobler, Gerhard
Kröger, Andrea
Överby, Anna K.
author_sort Kurhade, Chaitanya
collection PubMed
description We compared 2 tick-borne encephalitis virus strains isolated from 2 different foci that cause different symptoms in tick-borne encephalitis patients, from neurologic to mild gastrointestinal symptoms. We compared neuroinvasiveness, neurovirulence, and proinflammatory cytokine response in mice and found unique differences that contribute to our understanding of pathogenesis.
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spelling pubmed-61064202018-09-01 Correlation of Severity of Human Tick-Borne Encephalitis Virus Disease and Pathogenicity in Mice Kurhade, Chaitanya Schreier, Sarah Lee, Yi-Ping Zegenhagen, Loreen Hjertqvist, Marika Dobler, Gerhard Kröger, Andrea Överby, Anna K. Emerg Infect Dis Dispatch We compared 2 tick-borne encephalitis virus strains isolated from 2 different foci that cause different symptoms in tick-borne encephalitis patients, from neurologic to mild gastrointestinal symptoms. We compared neuroinvasiveness, neurovirulence, and proinflammatory cytokine response in mice and found unique differences that contribute to our understanding of pathogenesis. Centers for Disease Control and Prevention 2018-09 /pmc/articles/PMC6106420/ /pubmed/30124404 http://dx.doi.org/10.3201/eid2409.171825 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Dispatch
Kurhade, Chaitanya
Schreier, Sarah
Lee, Yi-Ping
Zegenhagen, Loreen
Hjertqvist, Marika
Dobler, Gerhard
Kröger, Andrea
Överby, Anna K.
Correlation of Severity of Human Tick-Borne Encephalitis Virus Disease and Pathogenicity in Mice
title Correlation of Severity of Human Tick-Borne Encephalitis Virus Disease and Pathogenicity in Mice
title_full Correlation of Severity of Human Tick-Borne Encephalitis Virus Disease and Pathogenicity in Mice
title_fullStr Correlation of Severity of Human Tick-Borne Encephalitis Virus Disease and Pathogenicity in Mice
title_full_unstemmed Correlation of Severity of Human Tick-Borne Encephalitis Virus Disease and Pathogenicity in Mice
title_short Correlation of Severity of Human Tick-Borne Encephalitis Virus Disease and Pathogenicity in Mice
title_sort correlation of severity of human tick-borne encephalitis virus disease and pathogenicity in mice
topic Dispatch
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6106420/
https://www.ncbi.nlm.nih.gov/pubmed/30124404
http://dx.doi.org/10.3201/eid2409.171825
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