Misidentification of runs of homozygosity islands in cattle caused by interference with copy number variation or large intermarker distances

BACKGROUND: Runs of homozygosity (ROH) islands are stretches of homozygous sequence in the genome of a large proportion of individuals in a population. Algorithms for the detection of ROH depend on the similarity of haplotypes. Coverage gaps and copy number variants (CNV) may result in incorrect ide...

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Detalles Bibliográficos
Autores principales: Nandolo, Wilson, Utsunomiya, Yuri T., Mészáros, Gábor, Wurzinger, Maria, Khayadzadeh, Negar, Torrecilha, Rafaela B. P., Mulindwa, Henry A., Gondwe, Timothy N., Waldmann, Patrik, Ferenčaković, Maja, Garcia, José F., Rosen, Benjamin D., Bickhart, Derek, van Tassell, Curt P., Curik, Ino, Sölkner, Johann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6106898/
https://www.ncbi.nlm.nih.gov/pubmed/30134820
http://dx.doi.org/10.1186/s12711-018-0414-x

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