Cardiomyocytes cultured on mechanically compliant substrates, but not on conventional culture devices, exhibit prominent mitochondrial dysfunction due to reactive oxygen species and insulin resistance under high glucose

RATIONALE: Diabetes causes cardiac dysfunction, and understanding of its mechanism is still incomplete. One reason could be limitations in modeling disease conditions by current in vitro cardiomyocyte culture. Emerging evidence suggests that the mechanical properties of the microenvironment affect c...

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Detalles Bibliográficos
Autores principales: Morishima, Masaki, Horikawa, Kazuki, Funaki, Makoto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107143/
https://www.ncbi.nlm.nih.gov/pubmed/30138395
http://dx.doi.org/10.1371/journal.pone.0201891

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107143/
https://www.ncbi.nlm.nih.gov/pubmed/30138395
http://dx.doi.org/10.1371/journal.pone.0201891

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