Increased MMP activity in curved geometries disrupts the endothelial cell glycocalyx creating a proinflammatory environment

Wall shear stress gradients (WSSGs) induce an inflammatory phenotype in endothelial cells (ECs) which is hypothesized to be mediated by mechanotransduction through the EC glycocalyx (GCX). We used a three-dimensional in vitro cell culture model with a 180(o) curved geometry to investigate if WSSGs c...

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Detalles Bibliográficos
Autores principales: Cooper, Scott, Emmott, Alexander, McDonald, Karli K., Campeau, Marc-Antoine, Leask, Richard L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107195/
https://www.ncbi.nlm.nih.gov/pubmed/30138400
http://dx.doi.org/10.1371/journal.pone.0202526

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107195/
https://www.ncbi.nlm.nih.gov/pubmed/30138400
http://dx.doi.org/10.1371/journal.pone.0202526

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