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Increased MMP activity in curved geometries disrupts the endothelial cell glycocalyx creating a proinflammatory environment
Wall shear stress gradients (WSSGs) induce an inflammatory phenotype in endothelial cells (ECs) which is hypothesized to be mediated by mechanotransduction through the EC glycocalyx (GCX). We used a three-dimensional in vitro cell culture model with a 180(o) curved geometry to investigate if WSSGs c...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107195/ https://www.ncbi.nlm.nih.gov/pubmed/30138400 http://dx.doi.org/10.1371/journal.pone.0202526 |