Genetic, transcriptional and post-translational regulation of the programmed death protein ligand 1 in cancer: biology and clinical correlations

The programmed death protein 1 (PD-1) and its ligand (PD-L1) represent a well-characterized immune checkpoint in cancer, effectively targeted by monoclonal antibodies that are approved for routine clinical use. The regulation of PD-L1 expression is complex, varies between different tumor types and o...

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Detalles Bibliográficos
Autores principales: Zerdes, Ioannis, Matikas, Alexios, Bergh, Jonas, Rassidakis, George Z., Foukakis, Theodoros
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107481/
https://www.ncbi.nlm.nih.gov/pubmed/29765155
http://dx.doi.org/10.1038/s41388-018-0303-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107481/
https://www.ncbi.nlm.nih.gov/pubmed/29765155
http://dx.doi.org/10.1038/s41388-018-0303-3

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