Peptide-guided functionalization and macrocyclization of bioactive peptidosulfonamides by Pd(II)-catalyzed late-stage C–H activation

Peptides and peptidomimetics are emerging as an important class of clinic therapeutics. Here we report a peptide-guided method for the functionalization and macrocyclization of bioactive peptidosulfonamides by Pd(II)-catalyzed late-stage C–H activation. In this protocol, peptides act as internal dir...

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Detalles Bibliográficos
Autores principales: Tang, Jian, Chen, Hongfei, He, Yadong, Sheng, Wangjian, Bai, Qingqing, Wang, Huan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107497/
https://www.ncbi.nlm.nih.gov/pubmed/30139997
http://dx.doi.org/10.1038/s41467-018-05440-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107497/
https://www.ncbi.nlm.nih.gov/pubmed/30139997
http://dx.doi.org/10.1038/s41467-018-05440-w

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