Cargando…

Peptide-guided functionalization and macrocyclization of bioactive peptidosulfonamides by Pd(II)-catalyzed late-stage C–H activation

Peptides and peptidomimetics are emerging as an important class of clinic therapeutics. Here we report a peptide-guided method for the functionalization and macrocyclization of bioactive peptidosulfonamides by Pd(II)-catalyzed late-stage C–H activation. In this protocol, peptides act as internal dir...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tang, Jian, Chen, Hongfei, He, Yadong, Sheng, Wangjian, Bai, Qingqing, Wang, Huan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107497/ https://www.ncbi.nlm.nih.gov/pubmed/30139997 http://dx.doi.org/10.1038/s41467-018-05440-w

Ejemplares similares

Synthesis of bioactive and stabilized cyclic peptides by macrocyclization using C(sp(3))–H activation
por: Tang, Jian, et al.
Publicado: (2017)

Dinitroimidazoles as bifunctional bioconjugation reagents for protein functionalization and peptide macrocyclization
por: Luo, Qunfeng, et al.
Publicado: (2019)

Enzyme-Catalyzed Macrocyclization of Long Unprotected Peptides
por: Zhang, Chi, et al.
Publicado: (2014)

Macrocyclization of peptidoarylacetamides with self-assembly properties through late-stage palladium-catalyzed C(sp(2))▬H olefination
por: Tan, Jiantao, et al.
Publicado: (2019)

Increasing the bioactive space of peptide macrocycles by thioamide substitution
por: Verma, Hitesh, et al.
Publicado: (2018)

Diversity-oriented synthesis of analogues of the novel macrocyclic peptide FR-225497 through late stage functionalization
por: Mukherjee, Jyotiprasad, et al.
Publicado: (2015)

Streamlined construction of peptide macrocycles via palladium-catalyzed intramolecular S-arylation in solution and on DNA
por: Yang, Peng, et al.
Publicado: (2021)

Structural Characterization of a Macrocyclic Peptide Modulator of the PD-1/PD-L1 Immune Checkpoint Axis
por: Zyla, Edyta, et al.
Publicado: (2021)

Late-Stage Modification of Medicine: Pd-Catalyzed Direct Synthesis and Biological Evaluation of N-Aryltacrine Derivatives
por: Wan, Lin-Xi, et al.
Publicado: (2021)

Biosynthetic Strategies for Macrocyclic Peptides
por: Wang, Wei, et al.
Publicado: (2021)

RNA-Binding Macrocyclic Peptides
por: Pal, Sunit, et al.
Publicado: (2022)

Evaluation of a Radiolabeled Macrocyclic Peptide as Potential PET Imaging Probe for PD−L1
por: Jouini, Nedra, et al.
Publicado: (2022)

Rational synthesis of benzimidazole[3]arenes by Cu(II)-catalyzed post-macrocyclization transformation
por: Tashiro, Shohei, et al.
Publicado: (2018)

Rational design of a potent macrocyclic peptide inhibitor targeting the PD-1/PD-L1 protein–protein interaction
por: Miao, Qi, et al.
Publicado: (2021)

Recent Advances on Macrocyclic Trichothecenes, Their Bioactivities and Biosynthetic Pathway
por: Zhu, Muzi, et al.
Publicado: (2020)

Macrocyclization strategies for cyclic peptides and peptidomimetics
por: Bechtler, Clément, et al.
Publicado: (2021)

Synthesis and direct assay of large macrocycle diversities by combinatorial late-stage modification at picomole scale
por: Habeshian, Sevan, et al.
Publicado: (2022)

Marine furanocembranoids-inspired macrocycles enabled by Pd-catalyzed unactivated C(sp(3))-H olefination mediated by donor/donor carbenes
por: Hao, Jiping, et al.
Publicado: (2021)

Late-stage stitching enabled by manganese-catalyzed C─H activation: Peptide ligation and access to cyclopeptides
por: Kaplaneris, Nikolaos, et al.
Publicado: (2021)

Late-stage peptide labeling with near-infrared fluorogenic nitrobenzodiazoles by manganese-catalyzed C–H activation
por: Oyama, Tsuyoshi, et al.
Publicado: (2023)

Development of the Inhibitors That Target the PD-1/PD-L1 Interaction—A Brief Look at Progress on Small Molecules, Peptides and Macrocycles
por: Guzik, Katarzyna, et al.
Publicado: (2019)

Bioinspired tetraamino-bisthiourea chiral macrocycles in catalyzing decarboxylative Mannich reactions
por: Guo, Hao, et al.
Publicado: (2022)

The Evolution of Pd(0)/Pd(II)-Catalyzed Aromatic Fluorination
por: Sather, Aaron C., et al.
Publicado: (2016)

Structural basis of ribosomal peptide macrocyclization in plants
por: Haywood, Joel, et al.
Publicado: (2018)

Rapid biocompatible macrocyclization of peptides with decafluoro-diphenylsulfone
por: Kalhor-Monfared, S., et al.
Publicado: (2016)

Peptidic Macrocycles - Conformational Sampling and Thermodynamic Characterization
por: Kamenik, Anna S., et al.
Publicado: (2018)

Recent Advances in Catalyzed Sequential Reactions and the Potential Use of Tetrapyrrolic Macrocycles as Catalysts
por: Santos, Everton Henrique, et al.
Publicado: (2018)

Technologies for the Synthesis of mRNA-Encoding Libraries and Discovery of Bioactive Natural Product-Inspired Non-Traditional Macrocyclic Peptides
por: Ito, Kenichiro, et al.
Publicado: (2013)

Insight into functionalized-macrocycles-guided supramolecular photocatalysis
por: Zuo, Minzan, et al.
Publicado: (2021)

Target-templated de novo design of macrocyclic d-/l-peptides: discovery of drug-like inhibitors of PD-1
por: Guardiola, Salvador, et al.
Publicado: (2021)

Photoredox Ni-catalyzed peptide C(sp(2))–O cross-coupling: from intermolecular reactions to side chain-to-tail macrocyclization
por: Lee, Hyelee, et al.
Publicado: (2019)

Correction: Rapid biocompatible macrocyclization of peptides with decafluoro-diphenylsulfone
por: Kalhor-Monfared, S., et al.
Publicado: (2017)

Macrocyclic Antimicrobial Peptides Engineered from ω-Conotoxin
por: Hemu, Xinya, et al.
Publicado: (2017)

Macrocyclic Tetramers—Structural Investigation of Peptide-Peptoid Hybrids
por: Herlan, Claudine Nicole, et al.
Publicado: (2021)

A chameleonic macrocyclic peptide with drug delivery applications
por: Payne, Colton D., et al.
Publicado: (2021)

Late-Stage Copper-Catalyzed Radiofluorination of an Arylboronic Ester Derivative of Atorvastatin
por: S. Clemente, Gonçalo, et al.
Publicado: (2019)

Palladium-Catalyzed Nondirected Late-Stage C–H Deuteration of Arenes
por: Farizyan, Mirxan, et al.
Publicado: (2021)

Synthesis and macrocyclization-induced emission enhancement of benzothiadiazole-based macrocycle
por: Li, Shuo, et al.
Publicado: (2022)

Enzymatic Late‐Stage Halogenation of Peptides
por: Schnepel, Christian, et al.
Publicado: (2022)

Second-Generation DNA-Templated Macrocycle Libraries for the Discovery of Bioactive Small Molecules
por: Usanov, Dmitry L., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_d530vfs109sk9lmcl4217n26mr