Polycomb complexes associate with enhancers and promote oncogenic transcriptional programs in cancer through multiple mechanisms

Polycomb repressive complex 1 (PRC1) plays essential roles in cell fate decisions and development. However, its role in cancer is less well understood. Here, we show that RNF2, encoding RING1B, and canonical PRC1 (cPRC1) genes are overexpressed in breast cancer. We find that cPRC1 complexes function...

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Detalles Bibliográficos
Autores principales: Chan, Ho Lam, Beckedorff, Felipe, Zhang, Yusheng, Garcia-Huidobro, Jenaro, Jiang, Hua, Colaprico, Antonio, Bilbao, Daniel, Figueroa, Maria E., LaCava, John, Shiekhattar, Ramin, Morey, Lluis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107513/
https://www.ncbi.nlm.nih.gov/pubmed/30139998
http://dx.doi.org/10.1038/s41467-018-05728-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107513/
https://www.ncbi.nlm.nih.gov/pubmed/30139998
http://dx.doi.org/10.1038/s41467-018-05728-x

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