The germline genetic component of drug sensitivity in cancer cell lines

Patients with seemingly the same tumour can respond very differently to treatment. There are strong, well-established effects of somatic mutations on drug efficacy, but there is at-most anecdotal evidence of a germline component to drug response. Here, we report a systematic survey of how inherited...

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Detalles Bibliográficos
Autores principales: Menden, Michael P., Casale, Francesco Paolo, Stephan, Johannes, Bignell, Graham R., Iorio, Francesco, McDermott, Ultan, Garnett, Mathew J., Saez-Rodriguez, Julio, Stegle, Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107640/
https://www.ncbi.nlm.nih.gov/pubmed/30139972
http://dx.doi.org/10.1038/s41467-018-05811-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107640/
https://www.ncbi.nlm.nih.gov/pubmed/30139972
http://dx.doi.org/10.1038/s41467-018-05811-3

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