Fatostatin induces pro- and anti-apoptotic lipid accumulation in breast cancer

Given the dependence of cancers on de novo lipogenesis, we tested the effect of fatostatin, a small molecule thought to target this pathway by blocking activation of SREBP transcription factors, in breast cancer cell lines and xenograft tumors. We found that estrogen receptor (ER) positive cells wer...

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Detalles Bibliográficos
Autores principales: Brovkovych, Viktor, Izhar, Yasir, Danes, Jeanne M., Dubrovskyi, Oleskii, Sakallioglu, Isin T., Morrow, Lauren M., Atilla-Gokcumen, G. Ekin, Frasor, Jonna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107643/
https://www.ncbi.nlm.nih.gov/pubmed/30140005
http://dx.doi.org/10.1038/s41389-018-0076-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107643/
https://www.ncbi.nlm.nih.gov/pubmed/30140005
http://dx.doi.org/10.1038/s41389-018-0076-0

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