Structural basis for polymerase η–promoted resistance to the anticancer nucleoside analog cytarabine

Cytarabine (AraC) is an essential chemotherapeutic for acute myeloid leukemia (AML) and resistance to this drug is a major cause of treatment failure. AraC is a nucleoside analog that differs from 2′-deoxycytidine only by the presence of an additional hydroxyl group at the C2′ position of the 2′-deo...

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Detalles Bibliográficos
Autores principales: Rechkoblit, Olga, Choudhury, Jayati Roy, Buku, Angeliki, Prakash, Louise, Prakash, Satya, Aggarwal, Aneel K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107656/
https://www.ncbi.nlm.nih.gov/pubmed/30140014
http://dx.doi.org/10.1038/s41598-018-30796-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107656/
https://www.ncbi.nlm.nih.gov/pubmed/30140014
http://dx.doi.org/10.1038/s41598-018-30796-w

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