Preferential Binding of Mg(2+) Over Ca(2+) to CIB2 Triggers an Allosteric Switch Impaired in Usher Syndrome Type 1J

Calcium and integrin binding protein 2 (CIB2) shares with the other members of the CIB family the ability to bind Ca(2+) and Mg(2+) via two functional EF-hand motifs, namely EF3 and EF4. As a cation sensor, CIB2 is able to switch to a conformation likely associated with specific biological functions...

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Detalles Bibliográficos
Autores principales: Vallone, Rosario, Dal Cortivo, Giuditta, D'Onofrio, Mariapina, Dell'Orco, Daniele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107761/
https://www.ncbi.nlm.nih.gov/pubmed/30174586
http://dx.doi.org/10.3389/fnmol.2018.00274

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107761/
https://www.ncbi.nlm.nih.gov/pubmed/30174586
http://dx.doi.org/10.3389/fnmol.2018.00274

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