Target-Based Discovery of an Inhibitor of the Regulatory Phosphatase PPP1R15B

Protein phosphorylation is a prevalent and ubiquitous mechanism of regulation. Kinases are popular drug targets, but identifying selective phosphatase inhibitors has been challenging. Here, we used surface plasmon resonance to design a method to enable target-based discovery of selective serine/thre...

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Detalles Bibliográficos
Autores principales: Krzyzosiak, Agnieszka, Sigurdardottir, Anna, Luh, Laura, Carrara, Marta, Das, Indrajit, Schneider, Kim, Bertolotti, Anne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6108835/
https://www.ncbi.nlm.nih.gov/pubmed/30057111
http://dx.doi.org/10.1016/j.cell.2018.06.030

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6108835/
https://www.ncbi.nlm.nih.gov/pubmed/30057111
http://dx.doi.org/10.1016/j.cell.2018.06.030

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