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Target-Based Discovery of an Inhibitor of the Regulatory Phosphatase PPP1R15B

Protein phosphorylation is a prevalent and ubiquitous mechanism of regulation. Kinases are popular drug targets, but identifying selective phosphatase inhibitors has been challenging. Here, we used surface plasmon resonance to design a method to enable target-based discovery of selective serine/thre...

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Detalles Bibliográficos
Autores principales:	Krzyzosiak, Agnieszka, Sigurdardottir, Anna, Luh, Laura, Carrara, Marta, Das, Indrajit, Schneider, Kim, Bertolotti, Anne
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6108835/ https://www.ncbi.nlm.nih.gov/pubmed/30057111 http://dx.doi.org/10.1016/j.cell.2018.06.030

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