The dual methyltransferase METTL13 targets N terminus and Lys55 of eEF1A and modulates codon-specific translation rates

Eukaryotic elongation factor 1 alpha (eEF1A) delivers aminoacyl-tRNA to the ribosome and thereby plays a key role in protein synthesis. Human eEF1A is subject to extensive post-translational methylation, but several of the responsible enzymes remain unknown. Using a wide range of experimental approa...

Descripción completa

Detalles Bibliográficos
Autores principales: Jakobsson, Magnus E., Małecki, Jędrzej M., Halabelian, Levon, Nilges, Benedikt S., Pinto, Rita, Kudithipudi, Srikanth, Munk, Stephanie, Davydova, Erna, Zuhairi, Fawzi R., Arrowsmith, Cheryl H., Jeltsch, Albert, Leidel, Sebastian A., Olsen, Jesper V., Falnes, Pål Ø.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109062/
https://www.ncbi.nlm.nih.gov/pubmed/30143613
http://dx.doi.org/10.1038/s41467-018-05646-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109062/
https://www.ncbi.nlm.nih.gov/pubmed/30143613
http://dx.doi.org/10.1038/s41467-018-05646-y

Ejemplares similares