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The dual methyltransferase METTL13 targets N terminus and Lys55 of eEF1A and modulates codon-specific translation rates
Eukaryotic elongation factor 1 alpha (eEF1A) delivers aminoacyl-tRNA to the ribosome and thereby plays a key role in protein synthesis. Human eEF1A is subject to extensive post-translational methylation, but several of the responsible enzymes remain unknown. Using a wide range of experimental approa...
Autores principales: | Jakobsson, Magnus E., Małecki, Jędrzej M., Halabelian, Levon, Nilges, Benedikt S., Pinto, Rita, Kudithipudi, Srikanth, Munk, Stephanie, Davydova, Erna, Zuhairi, Fawzi R., Arrowsmith, Cheryl H., Jeltsch, Albert, Leidel, Sebastian A., Olsen, Jesper V., Falnes, Pål Ø. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109062/ https://www.ncbi.nlm.nih.gov/pubmed/30143613 http://dx.doi.org/10.1038/s41467-018-05646-y |
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