Mutant KLF1 in Adult Anemic Nan Mice Leads to Profound Transcriptome Changes and Disordered Erythropoiesis

Anemic Nan mice carry a mutation (E339D) in the second zinc finger of erythroid transcription factor KLF1. Nan-KLF1 fails to bind a subset of normal KLF1 targets and ectopically binds a large set of genes not normally engaged by KLF1, resulting in a corrupted fetal liver transcriptome. Here, we perf...

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Detalles Bibliográficos
Autores principales: Nébor, Danitza, Graber, Joel H., Ciciotte, Steven L., Robledo, Raymond F., Papoin, Julien, Hartman, Emily, Gillinder, Kevin R., Perkins, Andrew C., Bieker, James J., Blanc, Lionel, Peters, Luanne L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109071/
https://www.ncbi.nlm.nih.gov/pubmed/30143664
http://dx.doi.org/10.1038/s41598-018-30839-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109071/
https://www.ncbi.nlm.nih.gov/pubmed/30143664
http://dx.doi.org/10.1038/s41598-018-30839-2

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