Mapping discontinuous epitopes for MRK-16, UIC2 and 4E3 antibodies to extracellular loops 1 and 4 of human P-glycoprotein

P-glycoprotein (P-gp), an ATP-dependent efflux pump, is associated with the development of multidrug resistance in cancer cells. Antibody-mediated blockade of human P-gp activity has been shown to overcome drug resistance by re-sensitizing resistant cancer cells to anticancer drugs. Despite the pote...

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Detalles Bibliográficos
Autores principales: Vahedi, Shahrooz, Lusvarghi, Sabrina, Pluchino, Kristen, Shafrir, Yinon, Durell, Stewart R., Gottesman, Michael M., Ambudkar, Suresh V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109178/
https://www.ncbi.nlm.nih.gov/pubmed/30143707
http://dx.doi.org/10.1038/s41598-018-30984-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109178/
https://www.ncbi.nlm.nih.gov/pubmed/30143707
http://dx.doi.org/10.1038/s41598-018-30984-8

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