The E3 SUMO ligase PIASγ is a novel interaction partner regulating the activity of diabetes associated hepatocyte nuclear factor-1α

The transcription factor hepatocyte nuclear factor-1α (HNF-1A) is involved in normal pancreas development and function. Rare variants in the HNF1A gene can cause monogenic diabetes, while common variants confer type 2 diabetes risk. The precise mechanisms for regulation of HNF-1A, including the role...

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Detalles Bibliográficos
Autores principales: Kaci, Alba, Keindl, Magdalena, Solheim, Marie H., Njølstad, Pål R., Bjørkhaug, Lise, Aukrust, Ingvild
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109179/
https://www.ncbi.nlm.nih.gov/pubmed/30143652
http://dx.doi.org/10.1038/s41598-018-29448-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109179/
https://www.ncbi.nlm.nih.gov/pubmed/30143652
http://dx.doi.org/10.1038/s41598-018-29448-w

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