Colesevelam attenuates cholestatic liver and bile duct injury in Mdr2(−/−) mice by modulating composition, signalling and excretion of faecal bile acids

BACKGROUND AND AIMS: Interruption of the enterohepatic circulation of bile acids (BAs) may protect against BA-mediated cholestatic liver and bile duct injury. BA sequestrants are established to treat cholestatic pruritus, but their impact on the underlying cholestasis is still unclear. We aimed to e...

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Detalles Bibliográficos
Autores principales: Fuchs, Claudia Daniela, Paumgartner, Gustav, Mlitz, Veronika, Kunczer, Victoria, Halilbasic, Emina, Leditznig, Nadja, Wahlström, Annika, Ståhlman, Marcus, Thüringer, Andrea, Kashofer, Karl, Stojakovic, Tatjana, Marschall, Hanns-Ulrich, Trauner, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2018
Materias:
Hepatology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109278/
https://www.ncbi.nlm.nih.gov/pubmed/29636383
http://dx.doi.org/10.1136/gutjnl-2017-314553

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109278/
https://www.ncbi.nlm.nih.gov/pubmed/29636383
http://dx.doi.org/10.1136/gutjnl-2017-314553

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