The CCR4-NOT complex is a tumor suppressor in Drosophila melanogaster eye cancer models

BACKGROUND: The CNOT3 protein is a subunit of the CCR4-NOT complex, which is involved in mRNA degradation. We recently identified CNOT3 loss-of-function mutations in patients with T-cell acute lymphoblastic leukemia (T-ALL). METHODS: Here, we use different Drosophila melanogaster eye cancer models t...

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Detalles Bibliográficos
Autores principales: Vicente, Carmen, Stirparo, Rocco, Demeyer, Sofie, de Bock, Charles E., Gielen, Olga, Atkins, Mardelle, Yan, Jiekun, Halder, Georg, Hassan, Bassem A., Cools, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109294/
https://www.ncbi.nlm.nih.gov/pubmed/30144809
http://dx.doi.org/10.1186/s13045-018-0650-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109294/
https://www.ncbi.nlm.nih.gov/pubmed/30144809
http://dx.doi.org/10.1186/s13045-018-0650-0

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