Prognostic significance of the programmed death ligand 1 expression in clear cell renal cell carcinoma and correlation with the tumor microenvironment and hypoxia-inducible factor expression

BACKGROUND: Clear cell renal cell carcinoma (ccRCC) is the most common renal malignancy. Hypoxia-inducible factors, HIF-1α and HIF-2α, are expressed in the majority of ccRCC. Targeting immune checkpoints with the blockade of PD-1 and its ligand PD-L1 reorganizes T-cell activity in tumor microenviron...

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Detalles Bibliográficos
Autores principales: Tatli Dogan, Hayriye, Kiran, Merve, Bilgin, Burak, Kiliçarslan, Aydan, Sendur, Mehmet Ali Nahit, Yalçin, Bülent, Ardiçoglu, Arslan, Atmaca, Ali Fuat, Gumuskaya, Berrak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109459/
https://www.ncbi.nlm.nih.gov/pubmed/30144808
http://dx.doi.org/10.1186/s13000-018-0742-8

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