HPLC Method for Quantification of Caffeine and Its Three Major Metabolites in Human Plasma Using Fetal Bovine Serum Matrix to Evaluate Prenatal Drug Exposure

Caffeine is recognized as the first-line therapeutic agent for apnea of prematurity. The dosage regimen is 10 mg/kg loading dose and 2.5 mg/kg maintenance dose. However, the plasma concentration achieved, not always, is therapeutically useful. It makes necessary to increase the doses to reach plasma...

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Detalles Bibliográficos
Autores principales: Lopez-Sanchez, Rosa del Carmen, Lara-Diaz, Victor Javier, Aranda-Gutierrez, Alejandro, Martinez-Cardona, Jorge A., Hernandez, Jose A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109507/
https://www.ncbi.nlm.nih.gov/pubmed/30186659
http://dx.doi.org/10.1155/2018/2085059

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109507/
https://www.ncbi.nlm.nih.gov/pubmed/30186659
http://dx.doi.org/10.1155/2018/2085059

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