Costimulation of Murine Osteoblasts with Interferon-γ and Tumor Necrosis Factor-α Induces Apoptosis through Downregulation of Bcl-2 and Release of Cytochrome c from Mitochondria

During chronic inflammation from diseases, such as periodontal disease, the proinflammatory cytokines interferon-gamma (IFNγ) and tumor necrosis factor-α (TNFα) alter bone remodeling. To elucidate the underlying molecular mechanisms, we investigated the effect of IFNγ and TNFα on the proliferation a...

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Detalles Bibliográficos
Autores principales: Iguchi, Mayumi, Hiroi, Miki, Kanegae, Haruhide, Ohmori, Yoshihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109523/
https://www.ncbi.nlm.nih.gov/pubmed/30158833
http://dx.doi.org/10.1155/2018/3979606

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109523/
https://www.ncbi.nlm.nih.gov/pubmed/30158833
http://dx.doi.org/10.1155/2018/3979606

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