Surface Probing by Fragment-Based Screening and Computational Methods Identifies Ligandable Pockets on the von Hippel–Lindau (VHL) E3 Ubiquitin Ligase

[Image: see text] Beyond the targeting of E3 ubiquitin ligases to inhibit protein homeostasis, E3 ligase binders can be repurposed as targeted protein degraders (PROTACs or molecular glues). We sought to identify new binders of the VHL E3 ligase by biophysical fragment-based screening followed by X-...

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Detalles Bibliográficos
Autores principales: Lucas, Xavier, Van Molle, Inge, Ciulli, Alessio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109845/
https://www.ncbi.nlm.nih.gov/pubmed/30040896
http://dx.doi.org/10.1021/acs.jmedchem.8b00842

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109845/
https://www.ncbi.nlm.nih.gov/pubmed/30040896
http://dx.doi.org/10.1021/acs.jmedchem.8b00842

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