Cargando…

Surface Probing by Fragment-Based Screening and Computational Methods Identifies Ligandable Pockets on the von Hippel–Lindau (VHL) E3 Ubiquitin Ligase

[Image: see text] Beyond the targeting of E3 ubiquitin ligases to inhibit protein homeostasis, E3 ligase binders can be repurposed as targeted protein degraders (PROTACs or molecular glues). We sought to identify new binders of the VHL E3 ligase by biophysical fragment-based screening followed by X-...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lucas, Xavier, Van Molle, Inge, Ciulli, Alessio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2018
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109845/ https://www.ncbi.nlm.nih.gov/pubmed/30040896 http://dx.doi.org/10.1021/acs.jmedchem.8b00842

Ejemplares similares

Targeting the von Hippel–Lindau E3 Ubiquitin Ligase Using Small Molecules To Disrupt the VHL/HIF-1α Interaction
por: Buckley, Dennis L., et al.
Publicado: (2012)

Discovery of small molecule ligands for the von Hippel-Lindau (VHL) E3 ligase and their use as inhibitors and PROTAC degraders
por: Diehl, Claudia J., et al.
Publicado: (2022)

Von Hippel–Lindau (VHL) small-molecule inhibitor binding increases stability and intracellular levels of VHL protein
por: Frost, Julianty, et al.
Publicado: (2021)

Structure-Guided Design and Optimization of Small Molecules Targeting the Protein–Protein Interaction between the von Hippel–Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities
por: Galdeano, Carles, et al.
Publicado: (2014)

Hemangioblast: origin of hemangioblastoma in von Hippel-Lindau (VHL) syndrome
por: Wang, Herui, et al.
Publicado: (2018)

The Role of VHL in the Development of von Hippel-Lindau Disease and Erythrocytosis
por: Hudler, Petra, et al.
Publicado: (2022)

Von Hippel–Lindau Disease (VHL): Characteristic Lesions with Classic Imaging Findings
por: Bajaj, Suryansh, et al.
Publicado: (2023)

Deciphering von Hippel-Lindau (VHL/Vhl)-Associated Pancreatic Manifestations by Inactivating Vhl in Specific Pancreatic Cell Populations
por: Shen, H.-C. Jennifer, et al.
Publicado: (2009)

Expression of Von Hippel – Lindau (VHL) gene mutation in diagnosed cases of renal cell carcinoma
por: Shahzad, Humera, et al.
Publicado: (2014)

The von Hippel–Lindau tumour suppressor gene: uncovering the expression of the pVHL172 isoform
por: Chesnel, F, et al.
Publicado: (2015)

A novel mutation in the VHL gene in a Chinese family with von Hippel-Lindau disease
por: Wu, Xing, et al.
Publicado: (2018)

Clinical diagnosis, treatment and screening of the VHL gene in three von Hippel-Lindau disease pedigrees
por: Lin, Guobing, et al.
Publicado: (2020)

Von Hippel-Lindau Disease
por: Hes, Frederik J, et al.
Publicado: (2005)

Expanding the Structural Diversity at the Phenylene Core of Ligands for the von Hippel–Lindau E3 Ubiquitin Ligase: Development of Highly Potent Hypoxia-Inducible Factor-1α Stabilizers
por: Vu, Lan Phuong, et al.
Publicado: (2023)

Sequencing of Von Hippel-Lindau (VHL) Gene from Genomic DNA for Mutation Detection in Italian Patients
por: Akanni, OE, et al.
Publicado: (2006)

Frequent Mutations of VHL Gene and the Clinical Phenotypes in the Largest Chinese Cohort With Von Hippel–Lindau Disease
por: Hong, Baoan, et al.
Publicado: (2019)

SUN-194 Adrenal Incidentaloma to Pheochromocytoma (Variant of Unknown Significance of Von Hippel Lindau Syndrome, VHL)
por: Oo, Yin Htwe
Publicado: (2020)

Von-Hippel Lindau (VHL) syndrome with bilateral cerebellar hemangioblastomas and retinal angiomas: A rare presentation
por: Acharya, Abhijit, et al.
Publicado: (2023)

Von Hippel-Lindau (VHL) Inactivation in Sporadic Clear Cell Renal Cancer: Associations with Germline VHL Polymorphisms and Etiologic Risk Factors
por: Moore, Lee E., et al.
Publicado: (2011)

Von Hippel-Lindau Disease and the Eye
por: Karimi, Saeed, et al.
Publicado: (2020)

The E3 ubiquitin-protein ligase MDM2 is a novel interactor of the von Hippel–Lindau tumor suppressor
por: Falconieri, Antonella, et al.
Publicado: (2020)

A patient with bilateral pheochromocytoma as part of a Von Hippel-Lindau (VHL) syndrome type 2C
por: Schreinemakers, Jennifer MJ, et al.
Publicado: (2007)

Design and Analysis of a Petri Net Model of the Von Hippel-Lindau (VHL) Tumor Suppressor Interaction Network
por: Minervini, Giovanni, et al.
Publicado: (2014)

Loss of Von Hippel–Lindau (VHL) Tumor Suppressor Gene Function: VHL–HIF Pathway and Advances in Treatments for Metastatic Renal Cell Carcinoma (RCC)
por: Kim, Hyunho, et al.
Publicado: (2021)

A Review of Von Hippel-Lindau Syndrome
por: Varshney, Neha, et al.
Publicado: (2017)

Cardiac Involvement in Von Hippel-Lindau Disease
por: Valero, Ernesto, et al.
Publicado: (2016)

Ocular Manifestations of von Hippel-Lindau Disease
por: Ruppert, Misty D, et al.
Publicado: (2019)

Novel interactions of the von Hippel-Lindau (pVHL) tumor suppressor with the CDKN1 family of cell cycle inhibitors
por: Minervini, Giovanni, et al.
Publicado: (2017)

A germline 1;3 translocation disrupting the VHL gene: a novel genetic cause for von Hippel-Lindau
por: Ricketts, Christopher J, et al.
Publicado: (2022)

Thioamide substitution to probe the hydroxyproline recognition of VHL ligands
por: Soares, Pedro, et al.
Publicado: (2018)

Recurrent lobular capillary hemangiomas in a patient with neurofibromatosis type 1 (NF1) and von Hippel-Lindau syndrome (VHL)
por: Haitz, Karyn, et al.
Publicado: (2015)

Molecular Characterization of a Novel Germline VHL Mutation by Extensive In Silico Analysis in an Indian Family with Von Hippel-Lindau Disease
por: Arunachal, Gautham, et al.
Publicado: (2016)

Inactivation of the tumor suppressor gene von Hippel-Lindau (VHL) in granulocytes contributes to development of liver hemangiomas in a mouse model
por: Bader, Hannah L., et al.
Publicado: (2016)

Hypoxia-inducible factor-2α stabilizes the von Hippel-Lindau (VHL) disease suppressor, Myb-related protein 2
por: Okumura, Fumihiko, et al.
Publicado: (2017)

Expression of von Hippel–Lindau tumor suppressor protein (pVHL) characteristic of tongue cancer and proliferative lesions in tongue epithelium
por: Hasegawa, Hisashi, et al.
Publicado: (2017)

Identification of a VHL gene mutation in atypical Von Hippel-Lindau syndrome: genotype–phenotype correlation and gene therapy perspective
por: Tong, Dali, et al.
Publicado: (2021)

Hemangioblastomatosis in a patient with von Hippel-Lindau disease
por: Hanse, M. C. J., et al.
Publicado: (2007)

The incidence of consecutive manifestations in Von Hippel-Lindau disease
por: van der Horst-Schrivers, Anouk N. A., et al.
Publicado: (2019)

Pathology of the Nervous System in Von Hippel-Lindau Disease
por: Vortmeyer, Alexander O., et al.
Publicado: (2015)

Resection of von Hippel Lindau Related Brainstem Hemangioblastoma
por: Maggio, Dominic, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_jom4ibk6ho73udhhkfrthkl4bt