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Structural and functional analysis of cystatin E reveals enzymologically relevant dimer and amyloid fibril states
Protein activity is often regulated by altering the oligomerization state. One mechanism of multimerization involves domain swapping, wherein proteins exchange parts of their structures and thereby form long-lived dimers or multimers. Domain swapping has been specifically observed in amyloidogenic p...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109925/ https://www.ncbi.nlm.nih.gov/pubmed/29967063 http://dx.doi.org/10.1074/jbc.RA118.002154 |