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Longitudinal decreases in multiple cerebrospinal fluid biomarkers of neuronal injury in symptomatic late onset Alzheimer’s disease
INTRODUCTION: Individuals in early stages of Alzheimer’s disease are a targeted population for secondary prevention trials aimed at preserving normal cognition. Understanding within-person biomarkers) change over time is critical for trial enrollment and design. METHODS: Longitudinal cerebrospinal f...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6110083/ https://www.ncbi.nlm.nih.gov/pubmed/29580670 http://dx.doi.org/10.1016/j.jalz.2018.01.012 |
Sumario: | INTRODUCTION: Individuals in early stages of Alzheimer’s disease are a targeted population for secondary prevention trials aimed at preserving normal cognition. Understanding within-person biomarkers) change over time is critical for trial enrollment and design. METHODS: Longitudinal cerebrospinal fluid samples from the Alzheimer’s Disease Neuroimaging Initiative were assayed for novel markers of neuronal/synaptic injury (visinin-like protein 1, Ng, and SNAP-25) and neuroinflammation (YKL-40) and compared with β amyloid 42, tau, and phospho-tau181. General linear mixed models were used to compare within-person rates of change in three clinical groups (cognitively normal, mild cognitive impairment, and Alzheimer’s disease) further defined by β amyloid status. RESULTS: Levels of injury markers were highly positively correlated. Despite elevated baseline levels as a function of clinical status and amyloid-positivity, within-person decreases in these measures were observed in the early symptomatic, amyloid-positive Alzheimer’s disease group. DISCUSSION: Knowledge of within-person biomarker change will impact interpretation of biomarker outcomes in clinical trials that are dependent on disease stage. |
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