Predicting resistance of clinical Abl mutations to targeted kinase inhibitors using alchemical free-energy calculations

The therapeutic effect of targeted kinase inhibitors can be significantly reduced by intrinsic or acquired resistance mutations that modulate the affinity of the drug for the kinase. In cancer, the majority of missense mutations are rare, making it difficult to predict their impact on inhibitor affi...

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Detalles Bibliográficos
Autores principales: Hauser, Kevin, Negron, Christopher, Albanese, Steven K., Ray, Soumya, Steinbrecher, Thomas, Abel, Robert, Chodera, John D., Wang, Lingle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6110136/
https://www.ncbi.nlm.nih.gov/pubmed/30159405
http://dx.doi.org/10.1038/s42003-018-0075-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6110136/
https://www.ncbi.nlm.nih.gov/pubmed/30159405
http://dx.doi.org/10.1038/s42003-018-0075-x

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