CD28 deficiency leads to accumulation of germinal-center independent IgM(+) experienced B cells and to production of protective IgM during experimental malaria

Protective immunity to blood-stage malaria is attributed to Plasmodium-specific IgG and effector-memory T helper 1 (Th1) cells. However, mice lacking the costimulatory receptor CD28 (CD28KO) maintain chronic parasitemia at low levels and do not succumb to infection, suggesting that other immune resp...

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Detalles Bibliográficos
Autores principales: Borges da Silva, Henrique, Machado de Salles, Érika, Lima-Mauro, Eliana Faquim, Sardinha, Luiz Roberto, Álvarez, José Maria, D’Império Lima, Maria Regina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6110469/
https://www.ncbi.nlm.nih.gov/pubmed/30148845
http://dx.doi.org/10.1371/journal.pone.0202522

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6110469/
https://www.ncbi.nlm.nih.gov/pubmed/30148845
http://dx.doi.org/10.1371/journal.pone.0202522

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