LRRK2 kinase regulates α-synuclein propagation via RAB35 phosphorylation

Propagation of α-synuclein aggregates has been suggested as a contributing factor in Parkinson’s disease (PD) progression. However, the molecular mechanisms underlying α-synuclein aggregation are not fully understood. Here, we demonstrate in cell culture, nematode, and rodent models of PD that leuci...

Descripción completa

Detalles Bibliográficos
Autores principales: Bae, Eun-Jin, Kim, Dong-Kyu, Kim, Changyoun, Mante, Michael, Adame, Anthony, Rockenstein, Edward, Ulusoy, Ayse, Klinkenberg, Michael, Jeong, Ga Ram, Bae, Jae Ryul, Lee, Cheolsoon, Lee, He-Jin, Lee, Byung-Dae, Di Monte, Donato A., Masliah, Eliezer, Lee, Seung-Jae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6110743/
https://www.ncbi.nlm.nih.gov/pubmed/30150626
http://dx.doi.org/10.1038/s41467-018-05958-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6110743/
https://www.ncbi.nlm.nih.gov/pubmed/30150626
http://dx.doi.org/10.1038/s41467-018-05958-z

Ejemplares similares