HIV-1 intron-containing RNA expression induces innate immune activation and T cell dysfunction

Low levels of type I interferon (IFN-I) are thought to be a driving force for immune activation and T-cell exhaustion in HIV-1 infected individuals on combination antiretroviral therapy (cART), though the causative mechanisms for persistent IFN-I signaling have remained unclear. Here, we show Rev–CR...

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Detalles Bibliográficos
Autores principales: Akiyama, Hisashi, Miller, Caitlin M., Ettinger, Chelsea R., Belkina, Anna C., Snyder-Cappione, Jennifer E., Gummuluru, Suryaram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6110775/
https://www.ncbi.nlm.nih.gov/pubmed/30150664
http://dx.doi.org/10.1038/s41467-018-05899-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6110775/
https://www.ncbi.nlm.nih.gov/pubmed/30150664
http://dx.doi.org/10.1038/s41467-018-05899-7

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