One-step process for production of N-methylated amino acids from sugars and methylamine using recombinant Corynebacterium glutamicum as biocatalyst

N-methylated amino acids are found in Nature in various biological compounds. N-methylation of amino acids has been shown to improve pharmacokinetic properties of peptide drugs due to conformational changes, improved proteolytic stability and/or higher lipophilicity. Due to these characteristics N-m...

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Detalles Bibliográficos
Autores principales: Mindt, Melanie, Risse, Joe Max, Gruß, Hendrik, Sewald, Norbert, Eikmanns, Bernhard J., Wendisch, Volker F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6110843/
https://www.ncbi.nlm.nih.gov/pubmed/30150644
http://dx.doi.org/10.1038/s41598-018-31309-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6110843/
https://www.ncbi.nlm.nih.gov/pubmed/30150644
http://dx.doi.org/10.1038/s41598-018-31309-5

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