Inhibition of Chloride Intracellular Channel 1 (CLIC1) as Biguanide Class-Effect to Impair Human Glioblastoma Stem Cell Viability

The antidiabetic biguanide metformin exerts antiproliferative effects in different solid tumors. However, during preclinical studies, metformin concentrations required to induce cell growth arrest were invariably within the mM range, thus difficult to translate in a clinical setting. Consequently, t...

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Detalles Bibliográficos
Autores principales: Barbieri, Federica, Würth, Roberto, Pattarozzi, Alessandra, Verduci, Ivan, Mazzola, Chiara, Cattaneo, Maria G., Tonelli, Michele, Solari, Agnese, Bajetto, Adriana, Daga, Antonio, Vicentini, Lucia M., Mazzanti, Michele, Florio, Tullio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6110922/
https://www.ncbi.nlm.nih.gov/pubmed/30186163
http://dx.doi.org/10.3389/fphar.2018.00899

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6110922/
https://www.ncbi.nlm.nih.gov/pubmed/30186163
http://dx.doi.org/10.3389/fphar.2018.00899

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