Cargando…

Inhibition of Chloride Intracellular Channel 1 (CLIC1) as Biguanide Class-Effect to Impair Human Glioblastoma Stem Cell Viability

The antidiabetic biguanide metformin exerts antiproliferative effects in different solid tumors. However, during preclinical studies, metformin concentrations required to induce cell growth arrest were invariably within the mM range, thus difficult to translate in a clinical setting. Consequently, t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Barbieri, Federica, Würth, Roberto, Pattarozzi, Alessandra, Verduci, Ivan, Mazzola, Chiara, Cattaneo, Maria G., Tonelli, Michele, Solari, Agnese, Bajetto, Adriana, Daga, Antonio, Vicentini, Lucia M., Mazzanti, Michele, Florio, Tullio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6110922/ https://www.ncbi.nlm.nih.gov/pubmed/30186163 http://dx.doi.org/10.3389/fphar.2018.00899

Ejemplares similares

Chloride intracellular channel 1 activity is not required for glioblastoma development but its inhibition dictates glioma stem cell responsivity to novel biguanide derivatives
por: Barbieri, Federica, et al.
Publicado: (2022)

Repurposed Biguanide Drugs in Glioblastoma Exert Antiproliferative Effects via the Inhibition of Intracellular Chloride Channel 1 Activity
por: Barbieri, Federica, et al.
Publicado: (2019)

Metformin repositioning as antitumoral agent: selective antiproliferative effects in human glioblastoma stem cells, via inhibition of CLIC1-mediated ion current
por: Gritti, Marta, et al.
Publicado: (2014)

Cellular prion protein controls stem cell-like properties of human glioblastoma tumor-initiating cells
por: Corsaro, Alessandro, et al.
Publicado: (2016)

Inhibition of the Autophagy Pathway Synergistically Potentiates the Cytotoxic Activity of Givinostat (ITF2357) on Human Glioblastoma Cancer Stem Cells
por: Angeletti, Francesca, et al.
Publicado: (2016)

Peptide Receptor Targeting in Cancer: The Somatostatin Paradigm
por: Barbieri, Federica, et al.
Publicado: (2013)

Different Effects of Human Umbilical Cord Mesenchymal Stem Cells on Glioblastoma Stem Cells by Direct Cell Interaction or Via Released Soluble Factors
por: Bajetto, Adriana, et al.
Publicado: (2017)

CXCL12 modulation of CXCR4 and CXCR7 activity in human glioblastoma stem-like cells and regulation of the tumor microenvironment
por: Würth, Roberto, et al.
Publicado: (2014)

The inhibition of FGF receptor 1 activity mediates sorafenib antiproliferative effects in human malignant pleural mesothelioma tumor-initiating cells
por: Pattarozzi, Alessandra, et al.
Publicado: (2017)

In vitro and in vivo antiproliferative activity of metformin on stem-like cells isolated from spontaneous canine mammary carcinomas: translational implications for human tumors
por: Barbieri, Federica, et al.
Publicado: (2015)

Role of Chemokine Network in the Development and Progression of Ovarian Cancer: A Potential Novel Pharmacological Target
por: Barbieri, Federica, et al.
Publicado: (2010)

Development of an Injectable Slow-Release Metformin Formulation and Evaluation of Its Potential Antitumor Effects
por: Baldassari, Sara, et al.
Publicado: (2018)

CLIC1 Protein Accumulates in Circulating Monocyte Membrane during Neurodegeneration
por: Carlini, Valentina, et al.
Publicado: (2020)

1-(4-Fluorophenyl)biguanid-1-ium chloride
por: Tutughamiarso, Maya, et al.
Publicado: (2010)

Transmembrane Chloride Intracellular Channel 1 (tmCLIC1) as a Potential Biomarker for Personalized Medicine
por: Cianci, Francesca, et al.
Publicado: (2021)

New Molecules and Old Drugs as Emerging Approaches to Selectively Target Human Glioblastoma Cancer Stem Cells
por: Würth, Roberto, et al.
Publicado: (2014)

Cross talk between mesenchymal and glioblastoma stem cells: Communication beyond controversies
por: Bajetto, Adriana, et al.
Publicado: (2020)

Contact allergy to polyhexamethylene biguanide (polyaminopropyl biguanide)
por: Sukakul, Thanisorn, et al.
Publicado: (2020)

Octreotide and Pasireotide Combination Treatment in Somatotroph Tumor Cells: Predominant Role of SST(2) in Mediating Ligand Effects
por: Amarù, Jessica, et al.
Publicado: (2021)

Experimental Evidence and Clinical Implications of Pituitary Adenoma Stem Cells
por: Würth, Roberto, et al.
Publicado: (2020)

Emerging Role of Cellular Prion Protein in the Maintenance and Expansion of Glioma Stem Cells †
por: Thellung, Stefano, et al.
Publicado: (2019)

Antiestrogen- and tamoxifen-induced effects on calcium-activated chloride currents in epithelial cells carrying the ∆F508-CFTR point mutation
por: Imberti, Roberto, et al.
Publicado: (2018)

Effects of biguanides on oxidative phosphorylation
por: Hirst, Judy
Publicado: (2014)

Synthetic accesses to biguanide compounds
por: Grytsai, Oleksandr, et al.
Publicado: (2021)

The cellular chloride channels CLIC1 and CLIC4 contribute to virus-mediated cell motility
por: Stakaitytė, Gabrielė, et al.
Publicado: (2018)

Biguanides and targeted anti-cancer treatments
por: Hanly, Elyse K., et al.
Publicado: (2015)

CXCR4 expression in feline mammary carcinoma cells: evidence of a proliferative role for the SDF-1/CXCR4 axis
por: Ferrari, Angelo, et al.
Publicado: (2012)

Double-Biguanide Therapy for Resistant Acanthamoeba Keratitis
por: Ferrari, Giulio, et al.
Publicado: (2011)

Toxicological assessment of polyhexamethylene biguanide for water treatment
por: Asiedu-Gyekye, Isaac J., et al.
Publicado: (2015)

Three Cases of Lactic Acidosis Caused by Biguanides
por: Kuwahara, Masaatsu, et al.
Publicado: (2022)

The Biguanides Metformin and Buformin in Combination with 2-Deoxy-glucose or WZB-117 Inhibit the Viability of Highly Resistant Human Lung Cancer Cells
por: Yakisich, Juan Sebastian, et al.
Publicado: (2019)

Preliminary Design of CLIC beam delivery System (CLIC BDS): Project Breakdown Structure (PBS): 4.1
por: Aloev, Alexander, et al.
Publicado: (2012)

Functional Role of CLIC1 Ion Channel in Glioblastoma-Derived Stem/Progenitor Cells
por: Setti, Matteo, et al.
Publicado: (2013)

Biophysical characterization of chloride intracellular channel 6 (CLIC6)
por: Loyo-Celis, Veronica, et al.
Publicado: (2023)

Energy balance at the organism and cellular level: effects of biguanides
por: Pollak, Michael
Publicado: (2014)

Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria
por: Bridges, Hannah R., et al.
Publicado: (2014)

In Vitro and In Vivo Modulation of Alternative Splicing by the Biguanide Metformin
por: Laustriat, Delphine, et al.
Publicado: (2015)

The effect of mouthwashes containing biguanides on the progression of erosion in dentin
por: Charone, Senda, et al.
Publicado: (2014)

Biguanides enhance antifungal activity against Candida glabrata
por: Xu, Shuying, et al.
Publicado: (2018)

Point Mutations in the Transmembrane Region of the Clic1 Ion Channel Selectively Modify Its Biophysical Properties
por: Averaimo, Stefania, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_3dkajrinujkfmdtearlla047us