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Ibuprofen nanocrystals developed by 2(2) factorial design experiment: A new approach for poorly water-soluble drugs
The reduction of the particle size of drugs of pharmaceutical interest down to the nano-sized range has dramatically changed their physicochemical properties. The greatest disadvantage of nanocrystals is their inherent instability, due to the risk of crystal growth. Thus, the selection of an appropr...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6111112/ https://www.ncbi.nlm.nih.gov/pubmed/30166898 http://dx.doi.org/10.1016/j.jsps.2017.07.004 |