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P-glycoprotein polymorphism and levothyroxine bioavailability in hypothyroid patients

OBJECTIVES: P-glycoprotein (P-gp) contributes to the disposition of a wide variety of drugs; therefore, single nucleotide polymorphisms (SNPs) in the P-gp coding gene might affect its activity. It is well known that personalized medicine, instead of empirical treatment, is a clinically important app...

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Detalles Bibliográficos
Autores principales: Öztaş, Ezgi, Parejo Garcia-Saavedra, Alejandro, Yanar, Fatih, Özçinar, Beyza, Aksakal, Nihat, Purisa, Sevim, Özhan, Gül
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6111188/
https://www.ncbi.nlm.nih.gov/pubmed/30166928
http://dx.doi.org/10.1016/j.jsps.2017.11.012