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Structure-Function Relationships of the Neisserial EptA Enzyme Responsible for Phosphoethanolamine Decoration of Lipid A: Rationale for Drug Targeting

Bacteria cause disease by two general mechanisms: the action of their toxins on host cells and induction of a pro-inflammatory response that can lead to a deleterious cytokine/chemokine response (e.g., the so-called cytokine storm) often seen in bacteremia/septicemia. These major mechanisms may over...

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Detalles Bibliográficos
Autores principales: Kahler, Charlene M., Nawrocki, K. L., Anandan, A., Vrielink, Alice, Shafer, William M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6111236/
https://www.ncbi.nlm.nih.gov/pubmed/30186254
http://dx.doi.org/10.3389/fmicb.2018.01922