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Dynamic redox balance directs the oocyte-to-embryo transition via developmentally controlled reactive cysteine changes
The metabolic and redox state changes during the transition from an arrested oocyte to a totipotent embryo remain uncharacterized. Here, we applied state-of-the-art, integrated methodologies to dissect these changes in Drosophila. We demonstrate that early embryos have a more oxidized state than mat...
Autores principales: | Petrova, Boryana, Liu, Keke, Tian, Caiping, Kitaoka, Maiko, Freinkman, Elizaveta, Yang, Jing, Orr-Weaver, Terry L. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6112717/ https://www.ncbi.nlm.nih.gov/pubmed/30082411 http://dx.doi.org/10.1073/pnas.1807918115 |
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