Codon usage influences fitness through RNA toxicity

Many organisms are subject to selective pressure that gives rise to unequal usage of synonymous codons, known as codon bias. To experimentally dissect the mechanisms of selection on synonymous sites, we expressed several hundred synonymous variants of the GFP gene in Escherichia coli, and used quant...

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Detalles Bibliográficos
Autores principales: Mittal, Pragya, Brindle, James, Stephen, Julie, Plotkin, Joshua B., Kudla, Grzegorz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6112741/
https://www.ncbi.nlm.nih.gov/pubmed/30082392
http://dx.doi.org/10.1073/pnas.1810022115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6112741/
https://www.ncbi.nlm.nih.gov/pubmed/30082392
http://dx.doi.org/10.1073/pnas.1810022115

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