Wild-type p53 oligomerizes more efficiently than p53 hot-spot mutants and overcomes mutant p53 gain-of-function via a “dominant-positive” mechanism

Human p53 protein acts as a transcription factor predominantly in a tetrameric form. Single residue changes, caused by hot-spot mutations of the TP53 gene in human cancer, transform wild-type (wt) p53 tumor suppressor proteins into potent oncoproteins - with gain-of-function, tumor-promoting activit...

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Detalles Bibliográficos
Autores principales: Walerych, Dawid, Pruszko, Magdalena, Zyla, Lukasz, Wezyk, Michalina, Gaweda-Walerych, Katarzyna, Zylicz, Alicja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6112834/
https://www.ncbi.nlm.nih.gov/pubmed/30174797
http://dx.doi.org/10.18632/oncotarget.25944

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6112834/
https://www.ncbi.nlm.nih.gov/pubmed/30174797
http://dx.doi.org/10.18632/oncotarget.25944

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