PAR1 signaling on tumor cells limits tumor growth by maintaining a mesenchymal phenotype in pancreatic cancer

Protease activated receptor-1 (PAR1) expression is associated with disease progression and overall survival in a variety of cancers. However, the importance of tumor cell PAR1 in pancreatic ductal adenocarcinomas (PDAC) remains unexplored. Utilizing orthotopic models with wild type and PAR1-targeted...

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Detalles Bibliográficos
Autores principales: Tekin, Cansu, Shi, Kun, Daalhuisen, Joost B., ten Brink, Marieke S., Bijlsma, Maarten F., Spek, C. Arnold
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6112838/
https://www.ncbi.nlm.nih.gov/pubmed/30174793
http://dx.doi.org/10.18632/oncotarget.25880

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6112838/
https://www.ncbi.nlm.nih.gov/pubmed/30174793
http://dx.doi.org/10.18632/oncotarget.25880

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