Contributions of rare coding variants in hypotension syndrome genes to population blood pressure variation

Rare variants, in particular renal salt handling genes, contribute to monogenic forms of hypertension and hypotension syndromes with electrolyte abnormalities. A study by Ji et al (2008) demonstrated this effect for rare loss-of-function coding variants in SLC12A3 (NCCT), SLC12A1 (NKCC2), and KCNJ1...

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Detalles Bibliográficos
Autores principales: Nandakumar, Priyanka, Morrison, Alanna C., Grove, Megan L., Boerwinkle, Eric, Chakravarti, Aravinda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113003/
https://www.ncbi.nlm.nih.gov/pubmed/30113482
http://dx.doi.org/10.1097/MD.0000000000011865

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113003/
https://www.ncbi.nlm.nih.gov/pubmed/30113482
http://dx.doi.org/10.1097/MD.0000000000011865

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