Leveraging PET to image folate receptor α therapy of an antibody-drug conjugate

BACKGROUND: The folate receptor α (FRα)-targeting antibody-drug conjugate (ADC), IMGN853, shows great antitumor activity against FRα-expressing tumors in vivo, but patient selection and consequently therapy outcome are based on immunohistochemistry. The aim of this study is to develop an antibody-de...

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Detalles Bibliográficos
Autores principales: Brand, Christian, Sadique, Ahmad, Houghton, Jacob L., Gangangari, Kishore, Ponte, Jose F., Lewis, Jason S., Pillarsetty, Naga Vara Kishore, Konner, Jason A., Reiner, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113196/
https://www.ncbi.nlm.nih.gov/pubmed/30155674
http://dx.doi.org/10.1186/s13550-018-0437-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113196/
https://www.ncbi.nlm.nih.gov/pubmed/30155674
http://dx.doi.org/10.1186/s13550-018-0437-x

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