A novel molecular rotor facilitates detection of p53-DNA interactions using the Fluorescent Intercalator Displacement Assay

We have investigated the use of fluorescent molecular rotors as probes for detection of p53 binding to DNA. These are a class of fluorophores that undergo twisted intramolecular charge transfer (TICT). They are non-fluorescent in a freely rotating conformation and experience a fluorescence increase...

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Detalles Bibliográficos
Autores principales: Goh, Walter L., Lee, Min Yen, Lim, Ting Xiang, Chua, Joy S., Brenner, Sydney, Ghadessy, Farid J., Teo, Yin Nah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113202/
https://www.ncbi.nlm.nih.gov/pubmed/30154420
http://dx.doi.org/10.1038/s41598-018-31197-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113202/
https://www.ncbi.nlm.nih.gov/pubmed/30154420
http://dx.doi.org/10.1038/s41598-018-31197-9

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