Tolerance to sustained activation of the cAMP/Creb pathway activity in osteoblastic cells is enabled by loss of p53

The loss of p53 function is a central event in the genesis of osteosarcoma (OS). How mutation of p53 enables OS development from osteoblastic lineage cells is poorly understood. We and others have reported a key role for elevated and persistent activation of the cAMP/PKA/Creb1 pathway in maintenance...

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Detalles Bibliográficos
Autores principales: Walia, Mannu K., Taylor, Scott, Ho, Patricia W. M., Martin, T. John, Walkley, Carl R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113249/
https://www.ncbi.nlm.nih.gov/pubmed/30154459
http://dx.doi.org/10.1038/s41419-018-0944-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113249/
https://www.ncbi.nlm.nih.gov/pubmed/30154459
http://dx.doi.org/10.1038/s41419-018-0944-8

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